Xiaflex Treatment for Dupuytren's Disease

Treatment with Xiaflex™ collagenase enzyme injections may help weaken and dissolve the diseased cords formed by Dupuytren's contracture without the need for open surgery.

Dupuytren’s disease, or Dupuytren’s contracture, causes an abnormal thickening of the tissue in the palm of the hand. As the disease progresses, a rope-like cord pulls the finger permanently toward the palm. This motion, called a contracture, makes it difficult to bend the fingers or fully open the hand.

Xiaflex™ is an FDA-approved prescription enzyme that is injected into a Dupuytren's cord to weaken it. The day after treatment, the physician forcefully stretches the affected finger to manually break or snap the cord and help restore full motion of the finger.

Possible side effects of Xiaflex™ treatment include swelling and/or bruising of the injection site or the hand, as well as pain, redness, itching and tenderness up the arm into the armpit. Less common side effects include tendon rupture, ligament damage, nerve injury or allergic reaction.

The hand specialists at Lancaster Orthopedic Group are experienced in the proper use and administration of Xiaflex™. If you suffer from Dupuytren’s disease, schedule an appointment with one of them to discuss the potential advantages of Xiaflex™ injections and other forms of treatment.